ERC Consolidator Grant · 2017
Septins: from bacterial entrapment to cellular immunity
The intracellular bacterium Shigella flexneri is an exceptional model pathogen to address key issues in biology, including how bacteria can move inside host cells and escape the immune system. The cytoskeleton has recently emerged to occupy a central role in innate immunity by promoting bacterial sensing and executing antibacterial functions. I discovered that host cells employ septins, a poorly understood component of the cytoskeleton, to restrict the actin-based motility of Shigella and target them for destruction by autophagy, an important mechanism of innate immune defence. However, the processes underlying septin cage assembly, and the breadth of roles for septins in bacterial…
From the public funding record at EU CORDIS. Describes the funded project, not the reviews below.
← All labs at London School of Hygiene and Tropical Medicine