ERC Consolidator Grant · 2022
Artificial RNA regulators to probe, control, and design gene regulatory networks in bacteria
RNA is common to all organisms. Despite its major function as the coding agent for protein synthesis, an increasing number of regulatory roles have been assigned to RNA. In bacteria, small RNAs (sRNAs) constitute the best-studied class of non-coding regulators estimated to control ~20% of all genes in a given organism. Most sRNAs affect gene expression by base-pairing with multiple target mRNAs resulting in either gene repression or activation. sRNA regulators are modular, versatile, and highly programmable, and thus have gathered momentum as control devices in synthetic biology and biotechnology. My group has recently established artificial sRNAs as a potent genetic tool to screen, detect,…
From the public funding record at EU CORDIS. Describes the funded project, not the reviews below.