ERC Advanced Grant · 2018
Unravelling the secretion machinery for virulence factors in apicomplexan parasites
Apicomplexan are obligatory intracellular parasites. The ability of these parasites (Plasmodium, Toxoplasma) to cause disease depends on the coordinated secretion of specialized secretory organelles. The rhoptries are particularly important, because they act as the apicomplexan equivalent of bacterial secretion systems. They inject parasite proteins directly in the cytoplasm of host cells not only for invasion but also to hijack host functions crucial to establish and maintain infection. However, in contrast to bacteria where the secretion machinery has been resolved to atomic detail, how eukaryotic parasites secrete and inject rhoptry effectors into cells is an enigma. This proposal aims…
From the public funding record at EU CORDIS. Describes the funded project, not the reviews below.
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