ERC Consolidator Grant · 2018
Spatiotemporal regulation of T-cell Priming
The initiation of adaptive cellular immunity requires antigen-specific interactions between Dendritic cells (DC) and naive CD8 T cells in secondary lymphoid organs. We aim to understand how the dynamic migratory behavior of myeloid and lymphoid cells is coordinated to ensure that “the right cells” communicate at “the right time” in “the right place” to enable robust immune responses. Using intravital microscopy, we have recently identified a critical phase (“Step 2”) of T cell priming that follows the initial encounter of DC and CD8 T cells and is essential to develop protective immunity. The aim of this proposal is to identify the cellular and molecular mechanisms regulating T cell…
From the public funding record at EU CORDIS. Describes the funded project, not the reviews below.