ERC Advanced Grant · 2019
Deciphering the unconventional receptor binding and modulation activity of bat influenza A viruses
Influenza A viruses (IAVs) are zoonotic pathogens that frequently cross the species barrier into humans, often causing severe morbidity and even global pandemics. This cross-species transmission is facilitated in large part by alterations in the interaction between the viral surface proteins hemagglutinin (HA) and neuraminidase (NA) and sialic acid, a ubiquitous glycan that serves as the cellular entry receptor. Although avian hosts have generally been thought to be the primary reservoir for all influenza A viruses, this dogma has recently been challenged by the identification of two novel IAV subtypes in bats, H17N10 and H18N11. Despite an otherwise high degree of functional homology to…
From the public funding record at EU CORDIS. Describes the funded project, not the reviews below.