ERC Starting Grant · 2019
Breaking the barrier: How inflammation spreads from skin to joint
Physical barriers of the body and their immunological dysregulation are connected to a variety of inflammatory diseases and therefore an emerging area of interest in medicine. The gut and its microbiome gained center stage, whereas the skin as large primary immunological barrier to the environment is still less appreciated. Psoriatic arthritis (PsA) is a prototypic inflammatory disease which usually starts with skin lesions, before spreading to the musculoskeletal regions. To date, it is still obscure why the inflammatory process in some patients with psoriasis is restrained to the skin, whereas in other patients it extends to tendons and joints. Moreover, disease spreading to the joints…
From the public funding record at EU CORDIS. Describes the funded project, not the reviews below.