ERC Consolidator Grant · 2020
Novel mechanisms of adaptive and innate bacteriophage immunity
Microbes are engaged in an evolutionary arms-race with their viruses and have evolved a spectrum of adaptive and innate defense systems to limit viral predation. Mechanistic insights into defense systems have yielded truly revolutionary genetic tools ranging from CRISPR-based genome editing nucleases to restriction enzymes used for molecular cloning. Despite the ongoing effort to understand defense systems, many antiviral defense systems remain virtually unstudied in and outside their native microbial context, creating huge potential for scientific breakthroughs and development of further game changing applications. In the timely research proposed here I aim to uncover how adaptive (CRISPR)…
From the public funding record at EU CORDIS. Describes the funded project, not the reviews below.