ERC Consolidator Grant · 2020
Regulation and relevance of circadian leukocyte dynamics for skin immune homeostasis
The skin is the largest organ of the body and represents the primary physical barrier to the environment. Circadian, ~24h rhythms in the environment have emerged as important regulators of the immune system, yet, the circadian dynamics of leukocyte turnover and function in the skin are completely unknown. Insights into the mechanisms occurring at this host-environment interface will be of key importance to understand how rhythmicity in the immune system is achieved. This will produce knowledge to optimize adjuvant design and maximize adaptive immune responses such as required in vaccinations, ultimately providing a time window for therapy. We will elucidate how circadian dynamics in…
From the public funding record at EU CORDIS. Describes the funded project, not the reviews below.