ERC Starting Grant · 2020
Microbiota dysbiosis is associated with chronic inflammatory diseases such as allergy, inflammatory bowel diseases, cancer and metabolism-related disorders. It has been reported that exposure to microbial and dietary components early in life may program the immune system to develop tolerance or susceptibility to chronic inflammatory diseases with age. We have recently showed that vigorous immune responses induced by gut microbiota at weaning, prevent the development and exacerbation of chronic inflammatory diseases in adult mice. Such immune alterations are termed the “weaning reaction”. Antibiotic exposure or excessive fats intake during this critical window deregulates the weaning…
From the public funding record at EU CORDIS. Describes the funded project, not the reviews below.