ERC Advanced Grant · 2021
Innate lymphoid cells and tissue adaptation to changing metabolic needs
Border surfaces of vertebrate organisms are in constant exchange with their habitat. Host cell networks consisting of epithelial cells, stroma and tissue-resident immune cells continuously integrate signals from the environment, a process by which an organism becomes better suited to its habitat (i.e., adaptation). Our understanding of the molecular underpinnings of such homeostatic processes is in its infancy, yet they are decisive for proper organ function. Recently, we and others have identified homeostatic circuitry involving tissue-resident immune cells in the small intestine facilitating adaptation to changes in nutrient cargo. The goal of my laboratory is to capture these molecular…
From the public funding record at EU CORDIS. Describes the funded project, not the reviews below.