Reber Lab

Research focus

ERC Consolidator Grant · 2021

Identification of long-term therapeutic strategy in IgE-mediated allergy by leveraging humanized models and patient samples

IgE is a key driver of allergic diseases, which affect approximately one-third of the world’s population. Monoclonal antibodies (mAbs) targeting IgE are approved for the treatment of allergic asthma, and show clinical benefit in a number of other allergic diseases. Yet, a sizable portion of patients do not respond to the drug despite high levels of IgE. There is a clear need to better define which allergy features depend (or not) on IgE, and to find predictive biomarkers in order to identify patients who will benefit from anti-IgE therapy. In addition, use of anti-IgE mAbs is limited by very high cost and the need to perform frequent reinfusion to maintain clinical efficiency. Combining…

From the public funding record at EU CORDIS. Describes the funded project, not the reviews below.