ERC Starting Grant · 2021
Tracing virus-specific CD8+ T cell clonotype zonation and function in humans
The current Covid-19 pandemic highlights the need to gain better understanding of precise mechanisms that enable immune control of viral infections. Although it is established that CD8+ T cells are required to suppress viremia, most view these cells simply as ?killer T cells? based almost exclusively on studies of blood. I recently discovered that efficient immune control of HIV is mediated primarily by non-killer resident memory CD8+ T cells, whereas CD8+ T cells with high ?killer instinct? are mainly confined to the vasculature. These observations force a reevaluation of how antiviral CD8+ T cells are distributed anatomically and function in the tissue spaces where most viruses replicate.…
From the public funding record at EU CORDIS. Describes the funded project, not the reviews below.