ERC Starting Grant · 2021
Deciphering commensal-host-pathogen metabolic interactions to combat intestinal infections
Our intestinal tract offers an attractive environment for bacteria. The beneficial bacteria of our microbiota feast on undigested foods and provide numerous health benefits. Enteric pathogens see this environment as an entry point for infection. Both groups influence each other, creating a tripartite interaction with us, the host. Understanding this interaction represents an emerging research area to combat infections poised to improve human health. Bacteroides are key commensals in these triangular interactions, as they produce diffusible intermediates as part of their metabolism that are utilized by pathogens and the host. These metabolites arise from the action of ~100 polysaccharide…
From the public funding record at EU CORDIS. Describes the funded project, not the reviews below.