ERC Starting Grant · 2021
T cell subsets underlying the rise, fall and recall of the Germinal Center
Follicular helper T cells (Tfh), through their cognate interactions with B cells, drive the Germinal Center (GC) reaction resulting in affinity matured memory B cells and Plasma cells, hallmarks of the adaptive immunity and underpinning our ability to counter pathogenic insults. For mounting a successful response against most pathogens, including the virus SarS-CoV-2 that has crippled most nations for over a year, Tfh cells are of central importance. Aberrant activation of Tfh has also been implicated in many diseases, including Multiple Sclerosis, Diabetes and Lymphoma. Understanding Tfh biology is essential for our understanding of the adaptive immune system and in our quest to develop…
From the public funding record at EU CORDIS. Describes the funded project, not the reviews below.