ERC Consolidator Grant · 2022
Charting Cell Type-Specific Nucleic Acid Immunity
Metabolic and immune pathways form an intricate network that maintains homeostasis. We recently unveiled that the Stimulator of Interferon Genes (STING), central to triggering cytosolic dsDNA-dependent type I Interferon (IFN) responses, inhibits the desaturation of essential dietary polyunsaturated fatty acids (PUFAs). STING thereby controls the generation of long-chain PUFAs (LC-PUFAs) that in turn inhibit STING activation. This double negative regulatory feedback loop operates as a key rheostat of homeostasis. Interestingly, we found that metabolic tissues, such adipose tissues, express low levels of STING, and that in vitro adipocyte differentiation leads to STING downregulation,…
From the public funding record at EU CORDIS. Describes the funded project, not the reviews below.
← All labs at National Centre for Scientific Research (CNRS)