ERC Consolidator Grant · 2022
Multi-omics characterization of immune triggers in Moyamoya disease
This project aims to characterize a recently discovered link between a rare genetic disorder of the brain, called Moyamoya disease (MMD), and the cellular immune response against microbial infections. MMD is characterized by a progressive occlusion of arteries at the base of the brain leading to stroke. Mutations in Ring Finger Protein 213 (RNF213) represent the most common genetic cause of MMD, however, it is suggested that environmental stimuli are needed to trigger disease onset in genetic carriers. Intriguingly, we recently discovered RNF213 as a novel antibacterial protein that can target intracellular Listeria (Gram+), providing strong protection to Listeria both in vitro and in vivo.…
From the public funding record at EU CORDIS. Describes the funded project, not the reviews below.