ERC Consolidator Grant · 2022
The malaria chemical atlas: Revealing the parasite-host functional interactome
Malaria is the most life-threatening parasitic disease in humans. Invasion of the malaria parasite, Plasmodium falciparum (Pf), into the blood circulation rewires the harmonious networking between the resident cells. Until recently, Pf was not thought to be able to communicate when nested within infected human red blood cells (RBCs). However, we and others have laid the foundations of Pf communication via extracellular vesicles. We now hypothesize that in order to survive in the hostile host environment, Pf secretes chemical inducers (e.g., metabolites, peptides) to actively coordinate life decisions as a group and to control the surrounding host cells. Remarkably, we obtained…
From the public funding record at EU CORDIS. Describes the funded project, not the reviews below.