Goujon Lab

National Institute of Health and Medical Research (INSERM)

Ile-de-France (FR1) · France

ERC-funded
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Research focus

ERC Consolidator Grant · 2022

Investigating Virus-Host Interplay in Human Primary Models of Genetically Modified Respiratory Epithelium

Respiratory viruses can rapidly spread worldwide with a devastating impact, as dramatically highlighted by the COVID-19 pandemic. In addition to the pandemic threat posed by influenza A viruses (IAV) or coronaviruses, respiratory viruses, including IAV, influenza B virus (IBV), seasonal coronaviruses and respiratory syncytial virus (RSV), are the cause of yearly epidemics, with a huge impact on human health. The vast majority of in vitro studies has been performed with model cancer cell lines. However, they share limited features with the primary cells found within the human respiratory epithelium. Robust and relevant, ex vivo models of human primary airway epithelia, cultured at the…

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