ERC Consolidator Grant · 2022
Mechanisms of dormancy, activation and sexual conversion in pre-erythrocytic malaria parasites
Malaria remains a devastating public health burden – the estimated death toll in 2020 was over 600,000. Its eradication is a desirable goal; however, the development of novel intervention strategies is hampered by limited current understanding of the biology of Plasmodium, the causative agent of malaria, and of its complex interactions with mammalian and mosquito hosts. In the liver, inside hepatocytes, Plasmodium parasites can either 1) replicate, forming new parasites that will infect erythrocytes and cause disease, or 2) remain dormant, which can lead to chronic, relapsing disease weeks to years after the original infection. I recently discovered new hepatic outcomes using a novel…
From the public funding record at EU CORDIS. Describes the funded project, not the reviews below.
← All labs at National Institute of Health and Medical Research (INSERM)