Merkling Lab

National Centre for Scientific Research (CNRS)

Ile-de-France (FR1) · France

ERC-funded
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ERC Starting Grant · 2022

Mosquito-virus matchmaking: Elucidating the biological basis of compatibility between viruses and mosquitoes

Half of the world’s population is at risk for mosquito-borne diseases. Yet, less than 3% of the mosquito species on earth can transmit pathogens to humans. Even within a species that specializes in biting humans and is the major vector for dengue virus (Aedes aegypti), mosquito populations on the globe transmit DENV with a wide range of efficiencies. Thus, some virus-mosquito pairs “match” with each other, and enable viral transmission, while others don’t. Understanding the biological processes that determine virus-mosquito compatibility is a longstanding question that has not yet been addressed, mostly owing to a lack of appropriate methods. Here, I propose to leverage advances in…

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