ERC Starting Grant · 2022
Deciphering the antibody-microbiota axis in early life
Immunoglobulins (Igs) are thought to influence formation of the microbiota composition during a critical window of opportunity in early life. Yet, the antigen binding profiles of these Igs are vastly unknown, and it is incompletely understood how early misguided immune education contributes to the development of allergies or asthma. On an even more fundamental level, it is also unclear if or how B cell receptor (BCR) sequences of different individuals converge to binding similar microbiota antigens and how such responses form in early life. Here, we will leverage phage display as well as novel approaches to study BCR sequence/Ig function relationships, focusing on the following objectives &…
From the public funding record at EU CORDIS. Describes the funded project, not the reviews below.