ERC Starting Grant · 2022
Decoding Requirements for Infiltration of T ceLLs into solid tumors
Cancer immunotherapies that leverage T cell activities are transforming cancer treatment. Currently, enormous effort has been devoted to empowering T cells to recognize and attack tumor cells. In contrast, the trafficking of T cells into tumors, a crucial prerequisite and limiting factor for effective T cell–tumor cell interactions, receives relatively less attention while at the same time being poorly understood. This is due to the complex and dynamic nature of T cell trafficking and the lack of model systems that allow function-based systematic investigation of the specific process. This proposal integrates innovative functional genomics into physiologically relevant models that…
From the public funding record at EU CORDIS. Describes the funded project, not the reviews below.