ERC Advanced Grant · 2023
Silent flagellin in chronic inflammatory and auto-immune disease
The last century has seen a dramatic increase in the prevalence of chronic inflammatory and autoimmune illnesses, including diseases of poorly understood etiology such as Crohn’s disease (CD) and myalgic encephalomyelitis (ME). Recent reports for CD and ME of elevated levels of antibodies against flagellins made by Lachnospiraceae (Lachno), which are usually associated with health, suggest a common breakdown of immune tolerance. My laboratory recently discovered a new class of flagellin that we termed “silent” because it binds the innate immune receptor TLR5 without inducing a response. Many Lachno species, which are highly abundant and prevalent in the human gut microbiome, encode silent…
From the public funding record at EU CORDIS. Describes the funded project, not the reviews below.