ERC Advanced Grant · 2023
PIWI-interacting RNAs at the interface of virus-host conflicts in Aedes aegypti mosquitoes
Background: The mosquito Aedes aegypti transmits viruses with pandemic potential but is also host to a large repertoire of mosquito-specific viruses and endogenous retroviruses. These viruses may invade the ovaries and eventually the oocyte to be transmitted from mother to offspring and to expand in the population. This transmission route exposes them to the specific host defense mechanisms of the ovary, which they must overcome to ensure onward transmission. This intriguing virus–host conflict is crucial for virus evolution and ecology and for host reproduction and survival, but has thus far not been studied. Hypothesis: I hypothesize that a specific class of small RNAs, called…
From the public funding record at EU CORDIS. Describes the funded project, not the reviews below.