ERC Consolidator Grant · 2023
Early life imprinting of B cell memory and its role in adult immunity
This proposal addresses the combined role of early life derived B cells in the adult immune system. Neonatal immune imprinting is now well-established concept. It emphasizes the importance of the early life window to establish host-microbial mutualism and the set-point for immune responsiveness later in life. However, the cellular and molecular mechanisms underlying this immune programming are not well understood. Despite the ability of B cells to integrate and store complex immunological memory for a lifetime, surprisingly little is known about its ability to confer the longitudinal effects of neonatal microbial instruction. By time-stamping B cells that arise early in life, my research…
From the public funding record at EU CORDIS. Describes the funded project, not the reviews below.