ERC Consolidator Grant · 2023
Negative Regulation of Inflammatory Responses Revealed with Camelid Nanobodies
The innate immune system evokes inflammation to control pathogens or damage. Sophisticated mechanisms interpret molecular triggers to activate inflammasomes or transcription of pro-inflammatory genes. While numerous autoinflammatory conditions underline the need to control inflammation, we still rely on simplistic models to understand its negative regulation. I hypothesize that an intricate signaling network interprets information to prevent or downregulate inflammation. Understanding these so far elusive processes demands radically new cell biology tools, which I will develop and apply in ‘DEFLAMMATION’. I propose to define signaling hubs that integrate cellular input and coordinate…
From the public funding record at EU CORDIS. Describes the funded project, not the reviews below.