Tamman Lab

University of Tartu

Eesti (EE0) · Estonia

ERC-funded
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ERC Starting Grant · 2023

Deciphering stringent response proteins and toxin-antitoxin systems in the arms race between bacteria and phages

Bacteriophages, viruses of bacteria, are the most abundant life form on Earth. The prospect of using them in the fight against pathogenic bacteria has long been recognised, but their very high specificity and unpredictable reproduction limits their use in medicine. The mechanisms phages use to fight bacteria are attractive candidates for the development of novel antimicrobial applications, but are still very poorly understood. Indirect evidence exists of toxin antitoxin systems (TAS) and stringent response involvement in phage defence. The constant co-evolution of phages and bacteria suggests that phages have a way of overcoming all of the wide variety of bacterial defence systems, yet, no…

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