ERC Starting Grant · 2023
Myeloid cells, such as dendritic cells (DCs) and neutrophils, reside in various organs to respond to insults and are key to control immunity and inflammation. However, their aberrant activities in the elderly can cause immunosenecence and inflammaging. Different tissues comprise highly distinct milieus that impose context-dependent biochemical challenges on their resident cells, which further change when tissues age. Yet, it is not known how DCs and neutrophils survive in their different homing organs and maintain their functionality. I hypothesize that DCs and neutrophils have to adjust their metabolism to the distinct environments of their tissues of residence. This is important, because…
From the public funding record at EU CORDIS. Describes the funded project, not the reviews below.
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