ERC Starting Grant · 2023
Engineered symbionts elucidate gut T cell memory and its (dys)regulation
A detailed understanding of intestinal T cell memory is crucial for novel treatments against inflammatory bowel disease but also for efficient vaccine design. Th cells induced by the gut microbiota are important for pathogen defence and tolerance, but it is unknown whether they form immunological memory characterised by long-term, antigen-independent maintenance. This has been due to the technical inability of disconnecting T cell induction from bacterial persistence in the gut. The GuT Memory project will yield unique insights into microbiota-directed Th cell memory and its (dys)regulation through uncoupling Th cell induction from luminal persistence of the microbe. Mutant strains of…
From the public funding record at EU CORDIS. Describes the funded project, not the reviews below.