ERC Advanced Grant · 2024
B cell-orchestrated tolerization of T cell-dependent B cell-mediated autoimmune diseases
Failure of thymic tolerance may result in severe autoimmune diseases that target the central nervous system (CNS), including Multiple Sclerosis (MS), Myelin Oligodendrocyte Glycoprotein (MOG)-associated Disease (MOGAD), and Neuromyelitis Optica Spectrum Disorders (NMOSD). Recently, we discovered a new layer of thymic tolerance in that thymic B cells get licensed to present activation-induced autoantigens, among them AQP4 (the target antigen in NMOSD). Thymic B cells are necessary and sufficient to purge the T cell repertoire of AQP4-specific clones. In BREAKING BAD, we will investigate in depth how thymic B cells shape the AQP4-specific T cell repertoire by either deleting AQP4-specific…
From the public funding record at EU CORDIS. Describes the funded project, not the reviews below.
← All labs at University Hospital Munich \Klinikum rechts der Isar\