ERC Advanced Grant · 2024
Age-associated antigens in atherosclerosis immunity and immunotherapy
Cardiovascular disease remains the leading cause of mortality worldwide, with atherosclerosis (AT) as the primary underlying factor. Ageing is the strongest risk factor for both AT and CVD. Emerging evidence indicates that the B cell-mediated immune response plays a pivotal role in the development and progression of AT, although the nature of this response and its triggering antigens are poorly understood. In our prior research, we identified ALDH4A1 as novel AT antigen and showed that anti-ALDH4A1 A12 antibody is atheroprotective in mice. Our recent preliminary data show increased titers of anti-ALDH4A1 antibodies in aged mice as well as a rise in age-associated B cells in AT mice. These…
From the public funding record at EU CORDIS. Describes the funded project, not the reviews below.
← All labs at National Centre for Cardiovascular Research - Spain