ERC Consolidator Grant · 2024
Discovering how T6SS effectors are deployed in the recipient cytoplasm
Interbacterial competition is a key driver of the emergence of new bacterial strains. A widely used strategy during interbacterial competition is delivering toxins into competitors’ cytoplasm, where they target conserved components. The type VI secretion system (T6SS), a machine that delivers toxic effectors into neighboring cells, is a major player in interbacterial competitions. It fires an effector-loaded tube that penetrates the recipient cell envelope. Although many T6SS effectors target the competitors’ cytoplasm, it is not known whether they are directly deployed there or rather deployed in the periplasm and then transported into the cytoplasm. We have recently identified several…
From the public funding record at EU CORDIS. Describes the funded project, not the reviews below.