ERC Starting Grant · 2024
Structure and Function-based Design of Vaccine Antigens and Antiviral Immunotherapies
Vaccines are critical in preventing viral diseases, and recent advances in vaccine development and delivery platforms have enhanced their reach and efficacy. Viral glycoproteins that mediate host cell entry are the primary target of the humoral immune response and thus the main antigenic component of vaccines. However, for many viruses, we lack fundamental biological insights that would easily allow transforming their glycoproteins into highly effective vaccine antigens. In this proposal, I introduce a completely novel approach to thoroughly extract structural and functional insights of viral glycoproteins for rational design of superior antigens. By conducting nanobody repertoire screens,…
From the public funding record at EU CORDIS. Describes the funded project, not the reviews below.