ERC Starting Grant · 2024
Shaping the bacterial envelope: Interplay between the components and impact on antibiotic resistance
Gram-negative bacteria are notoriously resilient, dominating the list of pathogens requiring urgent medical attention. Fundamental to their remarkable antibiotic resistance is a tripartite envelope comprised of an inner-membrane (IM), peptidoglycan cell wall (PG) and an outer membrane (OM). While these layers were previously viewed as separate compartments, it is becoming apparent that they work together in order to maintain envelope integrity. However, little is known about the crosstalk between components and molecular mechanisms orchestrating envelope assembly and functionality. Our latest work has identified a key interaction between the PG and the BAM complex which inserts new OM…
From the public funding record at EU CORDIS. Describes the funded project, not the reviews below.