Gaebler Lab

Charite - University Hospital Berlin

Berlin (DE3) · Germany

ERC-funded
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Research focus

ERC Starting Grant · 2024

Mission Remission: Integrated characterization of the HIV Reservoir and Host Immune Responses after Antibody-Immunotherapy

The search for a therapeutic intervention that can lead to HIV remission or cure is a global priority of the HIV field. HIV-specific antibodies have the potential to alter the clinical course of infection and enhance antiviral immune responses. In addition, we have recently demonstrated that antibody-based HIV immunotherapy results in higher-than-average cases of durable HIV remission in the absence of antiretroviral medication. Moreover, passive administration of HIV-specific antibodies was associated with reductions in the size of the replication-competent HIV reservoir which is the major barrier towards a cure for HIV. While these results highlight the exceptional potential of HIV…

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