ERC Starting Grant · 2024
Human genetic determinants of invasive group A streptococcal host-pathogen interactions
Group A streptococcus (GAS) is a major, human specific, bacterial pathogen. Most people suffer from mild infections, while only a few develop invasive GAS (iGAS) infections. These cases of iGAS infections are unexplained as they strike otherwise healthy people. The human specificity of GAS and the interindividual variability upon infection with GAS are poorly understood. My proposal aims to close both knowledge gaps: I hypothesize that single-gene defects of antistreptococcal immunity increase susceptibility to human-specific GAS virulence factors in some people, thereby underlying their iGAS infections. I propose an innovative framework to unravel iGAS pathophysiology in humans, by…
From the public funding record at EU CORDIS. Describes the funded project, not the reviews below.