ERC Starting Grant · 2024
Numerous mucosal vaccines and IgA-based monoclonal antibodies aimed at a robust immunity within the respiratory tract are in development to combat viral endemics and pandemics. However, investigations into humoral immunity have predominantly focused on circulating antibodies, particularly those of the IgG isotype. This has left a significant void in our understanding of the role of mucosal IgA proteoforms in conveying effective immune protection. This crucial knowledge gap deprives vaccine and antibody development of crucial determinants or immune characteristics to replicate. In response to this, we will conduct in-depth investigations of mucosal IgA including in vitro and in vivo…
From the public funding record at EU CORDIS. Describes the funded project, not the reviews below.