ERC Consolidator Grant · 2025
Unraveling tuft cell receptors and effector biosynthesis through interactome analysis
Complex organisms rely on specialized organ structures to interact with their environment, facilitating vital exchanges of molecules. The same structures create vulnerabilities to colonization by microorganisms, requiring sophisticated defense mechanisms. Central to these defenses is the innate immune system's ability to detect and rapidly respond to pathogens through diverse sensor mechanisms. While significant progress has been made in understanding the detection of viruses, bacteria, and fungi, critical gaps remain in how the innate immune system detects large, multicellular parasites like helminths, which pose substantial health challenges to humans and livestock. Tuft cells, rare…
From the public funding record at EU CORDIS. Describes the funded project, not the reviews below.