ERC Consolidator Grant · 2025
Cracking the Host Sugar Code: Insights into H5Nx Influenza A Virus Adaptation and Pathogenesis
Sugar-Viro will create advanced glycoscience tools to address critical questions in H5Nx influenza A virus (IAV) biology, aiming to enhance surveillance, inform antiviral development, and contribute to the fight against IAV infections. To initiate infection, respiratory pathogens like IAV must interact with complex carbohydrate structures, or glycans, present on the respiratory epithelium. However, virus-glycan interactions remain poorly understood due to the diversity, biosynthetic complexity, and multivalent presentation of host glycans. IAV, especially the H5Nx subtype, poses a continuous pandemic threat, recently spreading to a wider array of avian and mammalian hosts. This project will…
From the public funding record at EU CORDIS. Describes the funded project, not the reviews below.