ERC Consolidator Grant · 2025
Breaking the membranous refuge of intracellular bacteria
Many clinically important pathogens invade human cells and evade their intrinsic defenses by hiding within pathogen-containing vacuoles (PCVs). Hence, it may be feasible to combat such microbes by deliberately destabilizing their PCVs. To promote progress towards such an innovative therapeutic concept, I propose a 5-year research program in which my team will generate a molecular mechanistic understanding of how the PCV is maintained, how it can be destabilized, and how the consequences of PCV destabilization can be steered towards a beneficial outcome. We will focus on the inclusion, i.e., the PCV of Chlamydia trachomatis, as the strong host cell dependence of this leading bacterial cause…
From the public funding record at EU CORDIS. Describes the funded project, not the reviews below.