ERC Consolidator Grant · 2025
Decoding the immuno-regulatory functions of the human bone marrow niche upon cancer cellular therapy
ImmunhOss proposes the personalized modelling of cellular immunotherapies towards improving their efficacy in leukemia context. Cellular immunotherapies hold great clinical promises after demonstrating spectacular success in lymphomas and multiple myeloma, through the pioneering Chimeric Antigen Receptor T cells (CAR-Tc) strategy. However, the outcome remains poor for acute myeloid leukemia (AML) which accounts for the majority and most lethal adult leukemia. Pre-clinical successes were not followed by clinical efficacy, pointing at the substantial discrepancy between mouse models and patient response. In AML, evidence suggest a key role of the human bone marrow microenvironment, capable of…
From the public funding record at EU CORDIS. Describes the funded project, not the reviews below.