ERC Starting Grant · 2025
Antigenic and Topographical Imprinting of Human B Cell Memory and Its Reprogramming Potential
The novel COVID-19 vaccines have effectively reduced morbidity and mortality but unexpectedly failed to provide long-lasting sterilizing immunity. While specific serum antibody (Ab) titers were durable, local upper respiratory tract (URT) mucosal Ab responses were surprisingly short-lived. This shows both our lack of and need for a deeper understanding of URT mucosal immunity and its distinctions from systemic immunity. My proposal is designed to answer two key questions arising from this: How does the initial exposure site—mucosal or systemic—shape and imprint immune memory? And how is this imprinting reprogrammed by subsequent exposures via different exposure routes? In the TopBMemory…
From the public funding record at EU CORDIS. Describes the funded project, not the reviews below.