Šestan Lab

University of Rijeka - School of Medicine

Hrvatska (HR0) · Croatia

ERC-funded
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ERC Starting Grant · 2025

Every smell you take – Smell-induced conditioning of the immune system during infections

The nervous and immune systems are the body’s primary sensory interfaces, perceiving and responding to environmental stimuli. Both systems can recall past challenges, enabling them to mount responses that anticipate and adapt to ever-changing situation. Recent research indicates that the brain can recall past infections, forming a new axis between neurological memory and immune response. A notable example of such interaction is Pavlovian or classical conditioning, where organisms learn the timing and causal relationships between internal and external stimuli, enabling them to prepare responses before significant events even occur. Importantly, pioneering studies have shown that the immune…

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