ERC Starting Grant · 2025
DamAged memories: organelle heterogeneity en route to T cell diversity
Maintenance of long-lived and quiescent stem cells is impaired during ageing, which negatively impacts tissue regeneration by restricting cell diversity. In the context of T lymphocytes, ageing is linked to profound changes in their repertoire, which becomes less diverse due to naïve T cell attrition. This leads to the accumulation of terminally differentiated cells and results in poorer immune responses. I aim to understand whether T cell diversification is fostered by the unequal inheritance of heterogeneous pools of organelles with distinct chronological ages. I will focus on mitochondria and peroxisomes, as T cell metabolism is key to cell fate decisions. I hypothesize that i) organelle…
From the public funding record at EU CORDIS. Describes the funded project, not the reviews below.