ERC Starting Grant · 2025
Role of CD1c-reactive T cells and lipid antigens in post-streptococcal disease
Most T cell immunology knowledge is centered on T cell receptor (TCR) recognition of peptides presented by major histocompatibility complex (MHC) molecules. MHC class I-like CD1 proteins present lipid antigens to T cells, but it is becoming increasingly clear that the rules of lipid engagement show fundamental divergence from those of peptide recognition. As CD1 proteins are relatively monomorphic, solving the fundamental biology of lipid recognition opens the potential for wide therapeutic benefit. Group A Streptococcus (GAS) infection is associated with multiple autoimmune sequelae, yet the disease mechanisms are largely unexplained. Recent increases in GAS infection globally have re-…
From the public funding record at EU CORDIS. Describes the funded project, not the reviews below.