ERC Consolidator Grant · 2016
All-optical deconstruction of thalamic control of sleep-wake states.
While the functions of sleep are still a matter of debate and may include memory consolidation, brain clearance, anabolism and plasticity, the neural substrates of sleep and wake states are the subject of intense study. Successive sleep-wake cycles rely on an appropriate balance between sleep-promoting nuclei of the brain located in the anterior hypothalamus and, arousal-promoting nuclei from the posterior hypothalamus and the brainstem. My laboratory identified different subsets of hypothalamic cells that controls wakefulness and rapid-eye movement (also called paradoxical) sleep using optogenetics in combination with high-density electrophysiology in freely-behaving mice. We further…
From the public funding record at EU CORDIS. Describes the funded project, not the reviews below.