Bartos Lab

University Medical Center Freiburg

Baden-Württemberg (DE1) · Germany

ERC-funded
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ERC Advanced Grant · 2017

Role of GABAergic interneurons in the formation of new memory traces in the Dentate Gyrus of behaving mice

Despite intensive study in the past on the problem of how information is processed in the brain to enable individual organisms to adapt to their continuously changing environment, little progress has been made on how new similar but discrete memory traces emerge in neuronal networks during learning. Current theories suggest that experience-dependent modifications in excitation-inhibition balance enable a selected group of neurons to form a new cell association during learning which represent the new memory trace. It was further proposed that particularly GABAergic inhibitory interneurons (INs) have a large impact on population activity in neuronal networks by means of their inhibitory…

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