Korotkova Lab

University Hospital Cologne

Nordrhein-Westfalen (DEA) · Germany

ERC-funded
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Research focus

ERC Consolidator Grant · 2017

Dynamic regulation of feeding behaviors in health and disease by top-down control of hypothalamic networks

Feeding behaviors represent a complex set of crucial for survival abilities required to meet upcoming nutritional demands. Eating disorders, such as anorexia nervosa, are widespread, difficult to treat and extremely dangerous, displaying the highest mortality rate of all psychiatric disorders and a very high relapse rate. Mechanisms of onset, progression and relapse of eating disorders are unknown. Feeding behaviors are regulated by hypothalamus, an evolutionary conservative brain region. While a role of neurochemically defined hypothalamic neurons in feeding has been recently studied, little is known about an adaptive regulation of hypothalamus by extrahypothalamic inputs. Further, it is…

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