Makara Lab

Institute of Experimental Medicine - Hungary

Közép-Magyarország (HU1) · Hungary

ERC-funded
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ERC Consolidator Grant · 2017

Dendrites and memory: role of dendritic spikes in information coding by hippocampal CA3 pyramidal neurons

The hippocampus is essential for building episodic memories. Coding of locations, contexts or events in the hippocampus is based on the correlated activity of neuronal ensembles; however, the mechanisms promoting the recruitment of individual neurons into information-coding ensembles are poorly understood. In particular, the recurrent synaptic network of pyramidal cells (PCs) in the hippocampal CA3 area, receiving external inputs from the entorhinal cortex and the dentate gyrus, is thought to be essential for associative memory. Current models of the associative functions of CA3 are mainly based on plasticity of these synaptic connections. Recent work by us and others however suggests that…

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