Posthuma Lab

Research focus

ERC Advanced Grant · 2018

From GWAS to functional studies: Tackling the complex nature of brain disorders

Genome-wide association studies (GWAS) of unprecedented sample size have recently provided robust insight into the polygenic architecture of many different brain disorders. Despite this exciting potential, GWAS results have rarely translated into mechanistic disease insight. This is because the detected genetic effects are small and numerous, and hardly ever directly actionable for functional follow-up. In addition, the polygenic nature of brain disorders comes with large genetic heterogeneity, where different patients with the same disorder may carry completely different combinations of genetic risk variants, possibly corresponding to different etiological mechanisms, requiring different…

From the public funding record at EU CORDIS. Describes the funded project, not the reviews below.